Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H4WH
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Former ID |
DNC004726
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Drug Name |
Des-AA5-[D-Trp8]SRIF
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Synonyms |
CHEMBL408338; Des-AA5-[D-Trp8]SRIF
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C72H98N16O17S2
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Canonical SMILES |
CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CCCCN)NC(=O)CNC(=O)C(C)N)C(=O)O)CO)C(C)O)CC6=CC=CC=C6)O
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InChI |
1S/C72H98N16O17S2/c1-40(75)61(93)77-36-58(92)78-56-38-106-107-39-57(72(104)105)86-68(100)55(37-89)85-71(103)60(42(3)91)88-67(99)53(33-45-23-11-6-12-24-45)84-70(102)59(41(2)90)87-63(95)50(28-16-18-30-74)79-66(98)54(34-46-35-76-48-26-14-13-25-47(46)48)83-65(97)52(32-44-21-9-5-10-22-44)82-64(96)51(31-43-19-7-4-8-20-43)81-62(94)49(80-69(56)101)27-15-17-29-73/h4-14,19-26,35,40-42,49-57,59-60,76,89-91H,15-18,27-34,36-39,73-75H2,1-3H3,(H,77,93)(H,78,92)(H,79,98)(H,80,101)(H,81,94)(H,82,96)(H,83,97)(H,84,102)(H,85,103)(H,86,100)(H,87,95)(H,88,99)(H,104,105)/t40-,41+,42+,49+,50-,51+,52-,53-,54-,55-,56+,57-,59+,60+/m0/s1
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InChIKey |
ZIHRAPFYJSDXSV-BVGUNDCQSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Somatostatin receptor type 1 (SSTR1) | Target Info | Inhibitor | [2] |
Somatostatin receptor type 2 (SSTR2) | Target Info | Inhibitor | [2] | |
Somatostatin receptor type 3 (SSTR3) | Target Info | Inhibitor | [2] | |
Somatostatin receptor type 4 (SSTR4) | Target Info | Inhibitor | [2] | |
Somatostatin receptor type 5 (SSTR5) | Target Info | Inhibitor | [2] | |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Gastric acid secretion | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Pathwhiz Pathway | Gastric Acid Production | |||
Reactome | Peptide ligand-binding receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
GPCRs, Class A Rhodopsin-like | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2012). | |||
REF 2 | Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. |
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