Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0HH5B
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| Drug Name |
Benzimidazole derivative 15
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| Synonyms |
PMID28627961-Compound-7
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| Drug Type |
Small molecular drug
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| Company |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH PFAU, Roland ARNDT, Kirsten DOODS, Henri KLINDER, Klaus KUELZER, Raimund LUBRIKS, Dimitrijs MACK, Juergen PELCMAN, Benjamin PRIEPKE, Henning ROENN, Robert STENKAMP, Dirk SUNA, Edgars
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| Structure |
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Download2D MOL |
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| Formula |
C30H33F8N5O3
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| Canonical SMILES |
CC(C)(C)C(=O)NCC1=CC(=C(C=C1)C(F)(F)F)NC2=NC3=C(N2)C=C(C(=C3)OCC(F)F)C(=O)NC4CCC(CC4)C(F)(F)F
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| InChI |
1S/C30H33F8N5O3/c1-28(2,3)26(45)39-13-15-4-9-19(30(36,37)38)20(10-15)41-27-42-21-11-18(23(12-22(21)43-27)46-14-24(31)32)25(44)40-17-7-5-16(6-8-17)29(33,34)35/h4,9-12,16-17,24H,5-8,13-14H2,1-3H3,(H,39,45)(H,40,44)(H2,41,42,43)
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| InChIKey |
QUJFMVVWDBGGPL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin E synthase (PTGES) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Prostaglandin E synthase (PTGES) | Target's Patent Info | [1] | |
| BioCyc | C20 prostanoid biosynthesis | |||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Arachidonic acid metabolism | |||
| Eicosanoid Synthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. | |||
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