Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I4PX
|
|||
| Drug Name |
US8921389, 22
|
|||
| Synonyms |
CHEMBL3639707; SCHEMBL12503102; DKTMWXXXKCITJR-UHFFFAOYSA-N; BDBM141566; US8921389, 22; 3-[(1,3-Dibenzyl-5-hydroxy-2-oxo-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C31H26N4O5
|
|||
| Canonical SMILES |
C1=CC=C(C=C1)CC2=CC3=C(C(=NC(=C3O)C(=O)NCCC(=O)O)C4=CN=CC=C4)N(C2=O)CC5=CC=CC=C5
|
|||
| InChI |
1S/C31H26N4O5/c36-25(37)13-15-33-30(39)27-29(38)24-17-23(16-20-8-3-1-4-9-20)31(40)35(19-21-10-5-2-6-11-21)28(24)26(34-27)22-12-7-14-32-18-22/h1-12,14,17-18,38H,13,15-16,19H2,(H,33,39)(H,36,37)
|
|||
| InChIKey |
DKTMWXXXKCITJR-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase. US8921389. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.