Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I6ZS
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| Former ID |
DNC009184
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| Drug Name |
Dimethylnordihydroguarierate acid
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| Synonyms |
dimethylnordihydroguarierate acid; CHEMBL103600; AC1L9VQY; CTK7A7114; ZINC13780579; BDBM50065997; meso-1,4-Bis-(3-hydroxy-4-methoxyphenyl)-2,3-dimethylbutane; 5,5'-[(2R,3S)-2,3-Dimethyl-1,4-butanediyl]bis(2-methoxyphenol); 5-[(2S,3R)-4-(3-hydroxy-4-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol; 5-[(2r,3s)-4-(3-hydroxy-4-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol; 5-[4-(3-hydroxy-4-methoxyphenyl)-2,3-dimethyl-(2R,3S)-butyl]-2-methoxyphenol
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H26O4
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| Canonical SMILES |
CC(CC1=CC(=C(C=C1)OC)O)C(C)CC2=CC(=C(C=C2)OC)O
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| InChI |
1S/C20H26O4/c1-13(9-15-5-7-19(23-3)17(21)11-15)14(2)10-16-6-8-20(24-4)18(22)12-16/h5-8,11-14,21-22H,9-10H2,1-4H3/t13-,14+
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| InChIKey |
FHAGEYRSWPQEQJ-OKILXGFUSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 12-lipoxygenase (12-LOX) | Target Info | Inhibitor | [1] |
| Arachidonate 15-lipoxygenase (15-LOX) | Target Info | Inhibitor | [1] | |
| BioCyc | Resolvin D biosynthesis | |||
| Lipoxin biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Linoleic acid metabolism | ||||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| Pathway Interaction Database | IL4-mediated signaling events | |||
| WikiPathways | Arachidonic acid metabolism | |||
| Eicosanoid Synthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. | |||
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