Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I7OF
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| Drug Name |
Hexamethylene amiloride
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| Synonyms |
5-(N,N-Hexamethylene)amiloride; 5-HMA; BIDD; BSPBio_003443; C12H18ClN7O; DivK1c_006875; HMA; HMA-5; Hexamethyleneamiloride; KBioGR_001206; KBioSS_002076; Lopac-A-9561; Lopac0_000104; MLS002153208; N,N-HEXAMETHYLENEAMILORIDE; SPECTRUM1504215; SpecPlus_000779; Spectrum2_001669; Spectrum3_001662; Spectrum4_000623; Spectrum5_001388; Spectrum_001596
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| Drug Type |
Small molecular drug
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| Indication | Severe acute respiratory syndrome (SARS) [ICD-11: 1D65] | Preclinical | [1] | |
| Therapeutic Class |
Antiviral Agents
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| Structure |
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Download2D MOL |
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| Formula |
C12H18ClN7O
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| Canonical SMILES |
C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N
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| InChI |
1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)
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| InChIKey |
RQQJJXVETXFINY-UHFFFAOYSA-N
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| CAS Number |
CAS 1428-95-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:76400
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | SARS-CoV envelope small membrane protein (E) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. | |||
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