Target Information
Target General Information | Top | |||||
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Target ID |
T11566
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Target Name |
SARS-CoV envelope small membrane protein (E)
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Synonyms |
SARS-CoV E protein; SARS-CoV sM protein
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Gene Name |
SARS-CoV E; SARS-CoV 4; SARS-CoV sM
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Disease | [+] 1 Target-related Diseases | + | ||||
1 | Severe acute respiratory syndrome [ICD-11: 1D65] | |||||
Function |
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.
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BioChemical Class |
Betacoronaviruses E protein family.
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UniProt ID | ||||||
Sequence |
MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTVYVYS
RVKNLNSSEGVPDLLV Click to Show/Hide
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Drugs and Modes of Action | Top | |||||
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Preclinical Drugs | [+] 1 | + | ||||
1 | Hexamethylene amiloride | Drug Info | Preclinical | Severe acute respiratory syndrome (SARS) | [1] | |
Mode of Action | [+] 1 Modes of Action | + | ||||
Inhibitor | [+] 1 Inhibitor drugs | + | ||||
1 | Hexamethylene amiloride | Drug Info | [1] |
References | Top | |||||
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REF 1 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. |
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