Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IX1I
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| Former ID |
DIB003664
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| Drug Name |
NBI-98854
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| Synonyms |
NBI-98782; Vesicular monoamine transporter 2 inhibitor (CNS indications), Neurocrine; VMAT-2 inhibitor (CNS disease), Neurocrine
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| Drug Type |
Small molecular drug
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| Indication | Movement disorder [ICD-11: 8A07-8A0Z; ICD-10: G20-G26] | Phase 3 | [1], [2] | |
| Tourette syndrome [ICD-11: 8A05.00; ICD-10: F95.2] | Phase 2 | [3] | ||
| Company |
Neurocrine biosciences
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| Structure |
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Download2D MOL |
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| Formula |
C19H29NO3
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| Canonical SMILES |
CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1O)OC)OC
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| InChI |
1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3
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| InChIKey |
WEQLWGNDNRARGE-UHFFFAOYSA-N
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| CAS Number |
CAS 3466-75-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8694). | |||
| REF 2 | ClinicalTrials.gov (NCT02274558) A Phase 3 Study of NBI-98854 for the Treatment of Tardive Dyskinesia. U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 4 | NBI-98854, a selective monoamine transport inhibitor for the treatment of tardive dyskinesia: A randomized, double-blind, placebo-controlled study. Mov Disord. 2015 Oct;30(12):1681-7. | |||
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