Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0J2ID
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| Former ID |
DNC011042
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| Drug Name |
6-chloro-N-(pyridin-3-yl)indoline-1-carboxamide
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| Synonyms |
CHEMBL38911; 6-chloro-N-(pyridin-3-yl)indoline-1-carboxamide; SCHEMBL8526818; LOMPSBWQXLVHJX-UHFFFAOYSA-N; BDBM50321876; 6-Chloro-1-(3-pyridylcarbamoyl)indoline; N-(3-Pyridinyl)-6-chloro-2,3-dihydro-1H-indole-1-carboxamide; 6-Chloro-2,3-dihydro-indole-1-carboxylic acid pyridin-3-ylamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C14H12ClN3O
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| Canonical SMILES |
C1CN(C2=C1C=CC(=C2)Cl)C(=O)NC3=CN=CC=C3
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| InChI |
1S/C14H12ClN3O/c15-11-4-3-10-5-7-18(13(10)8-11)14(19)17-12-2-1-6-16-9-12/h1-4,6,8-9H,5,7H2,(H,17,19)
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| InChIKey |
LOMPSBWQXLVHJX-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
| 5-HT 2C receptor (HTR2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | |||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. | |||
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