Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0JD5W
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| Drug Name |
PMID27998201-Compound-7
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| Drug Type |
Small molecular drug
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| Indication | Abdominal aortic aneurysm [ICD-11: BD50.4; ICD-10: I71.3, I71.4] | Patented | [1] | |
| Company |
F. HOFFMANN-LA ROCHE AG HOFFMANN-LA ROCHE INC
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H21F2IN4O4S
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| Canonical SMILES |
C1CC1(C#N)NC(=O)C2CC(CN2C(=O)C3(CC3)C4=C(C=C(C=N4)I)F)S(=O)(=O)C5=CC=CC=C5F
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| InChI |
1S/C24H21F2IN4O4S/c25-16-3-1-2-4-19(16)36(34,35)15-10-18(21(32)30-23(13-28)5-6-23)31(12-15)22(33)24(7-8-24)20-17(26)9-14(27)11-29-20/h1-4,9,11,15,18H,5-8,10,12H2,(H,30,32)/t15-,18+/m1/s1
|
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| InChIKey |
ZEFHIBBPLAGQMT-QAPCUYQASA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin L (CTSL) | Target Info | Inhibitor | [1] |
| Cathepsin S (CTSS) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | Cathepsin L (CTSL) | Target's Patent Info | [1] | |
| Cathepsin S (CTSS) | Target's Patent Info | [1] | ||
| KEGG Pathway | Lysosome | |||
| Phagosome | ||||
| Antigen processing and presentation | ||||
| Proteoglycans in cancer | ||||
| Rheumatoid arthritis | ||||
| Tuberculosis | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Reactome | Endosomal/Vacuolar pathway | |||
| Collagen degradation | ||||
| Degradation of the extracellular matrix | ||||
| Trafficking and processing of endosomal TLR | ||||
| Assembly of collagen fibrils and other multimeric structures | ||||
| MHC class II antigen presentation | ||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
| Class I MHC mediated antigen processing & presentation | ||||
| Trafficking and processing of endosomal TLR | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. | |||
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