Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0JR2Q
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| Drug Name |
US10149841, Compound 1
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| Synonyms |
SCHEMBL19808953; US10149841, Compound 1; BDBM306795
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C14H12N2O5
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| Canonical SMILES |
C1=CC=C(C=C1)OC2=CC(=C(N=C2)C(=O)NCC(=O)O)O
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| InChI |
1S/C14H12N2O5/c17-11-6-10(21-9-4-2-1-3-5-9)7-15-13(11)14(20)16-8-12(18)19/h1-7,17H,8H2,(H,16,20)(H,18,19)
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| InChIKey |
SUWPOWJCFOLJFD-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof. US10149841. | |||
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