Drug Information
Drug General Information | Top | |||
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Drug ID |
D0JY5S
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Former ID |
DAP001109
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Drug Name |
Methantheline
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Synonyms |
Mantheline; Methanide; Methanthelinium; Methanthelinum; Banthine bromide; Gastrin I; Methanthine bromide; Gastrin-1 Human; Diethyl-methyl-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium; N,N-Diethyl-N-methyl-2-[(9H-xanthen-9-ylcarbonyl)oxy]ethanaminium
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Drug Type |
Small molecular drug
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Indication | Gastritis [ICD-11: DA42] | Approved | [1] | |
Irritable bowel syndrome [ICD-11: DD91.0; ICD-10: K55-K64, K58] | Approved | [1] | ||
Pancreatitis [ICD-11: DC31-DC34] | Approved | [1] | ||
Peptic ulcer [ICD-11: DA61] | Approved | [1] | ||
Therapeutic Class |
Anticholinergic Agents
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Company |
Shire Development Inc
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Structure |
Download2D MOL |
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Formula |
C21H26NO3+
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Canonical SMILES |
CC[N+](C)(CC)CCOC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13
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InChI |
1S/C21H26NO3/c1-4-22(3,5-2)14-15-24-21(23)20-16-10-6-8-12-18(16)25-19-13-9-7-11-17(19)20/h6-13,20H,4-5,14-15H2,1-3H3/q+1
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InChIKey |
GZHFODJQISUKAY-UHFFFAOYSA-N
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CAS Number |
CAS 5818-17-7
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PubChem Compound ID | ||||
PubChem Substance ID |
10051, 5065188, 7849622, 7979926, 8152569, 11112123, 11467094, 11468214, 11486702, 14802373, 29223206, 46505807, 47365391, 47440448, 48110636, 48185161, 49699275, 57322139, 79115168, 85209433, 85787544, 103828388, 104305419, 117579898, 123099364, 124881918, 128027980, 134338354, 134987914, 137004191, 179225196, 198968480, 223440306, 223509410, 226457267
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ChEBI ID |
CHEBI:6817
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SuperDrug ATC ID |
A03AB07
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SuperDrug CAS ID |
cas=005818177
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Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Coprococcus comes
Show/Hide Hierarchy
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Coprococcus comes was decreased by Methantheline bromide (adjusted p-values: 8.71E-03). |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
REF 3 | Anticholinergics for urinary symptoms in multiple sclerosis. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004193. |
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