Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0K0KH
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| Former ID |
DAP001534
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| Drug Name |
Tropisetron
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| Synonyms |
Navoban; Novaban; TKT; ICS-205930; Navoban (TN); Tropisetron (INN); [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylate
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| Drug Type |
Small molecular drug
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| Indication | Fibromyalgia [ICD-11: MG30.01; ICD-10: M79.7; ICD-9: 729.1] | Approved | [1], [2] | |
| Company |
Novartis International AG
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| Structure |
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Download2D MOL |
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| Formula |
C17H20N2O2
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| Canonical SMILES |
CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43
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| InChI |
1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13?
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| InChIKey |
ZNRGQMMCGHDTEI-FUNVUKJBSA-N
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| CAS Number |
CAS 89565-68-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
586259, 7849191, 7980847, 9268089, 11111839, 12013648, 15222410, 26755041, 32961435, 34873056, 47805530, 48404460, 57288867, 57408379, 78731080, 85176985, 92309072, 104003611, 104234183, 113528005, 124881513, 135651284, 136037819, 136212975, 137248058, 140119381, 140836794, 142488962, 144203823, 152109096, 162177588, 163621151, 163686496, 163719193, 170466432, 176484497, 179316852, 184545081, 184654810, 184812293, 198945704, 223441795, 226408320, 226408321, 226408322, 229923840, 238285228, 242115154, 245129894, 245216191
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| ChEBI ID |
CHEBI:32269
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| ADReCS Drug ID | BADD_D02304 | |||
| SuperDrug ATC ID |
A04AA03
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| SuperDrug CAS ID |
cas=089565684
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3A receptor (HTR3A) | Target Info | Antagonist | [2] |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | 5HT3 type receptor mediated signaling pathway | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 260). | |||
| REF 2 | Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. | |||
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