Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K4GK
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| Former ID |
DIB018533
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| Drug Name |
22R-hydroxycholesterol
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| Synonyms |
22beta-hydroxycholesterol; 22R-OHC
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C27H46O2
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| Canonical SMILES |
CC(C)CCC(C(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)O
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| InChI |
1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
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| InChIKey |
RZPAXNJLEKLXNO-GFKLAVDKSA-N
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| CAS Number |
CAS 17954-98-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7855, 7983970, 10256555, 17501138, 24895852, 46241149, 49688252, 57351298, 75005942, 103114776, 103162244, 103428723, 113461277, 123080470, 126524977, 127346295, 135123118, 135651388, 135764294, 137109197, 139022589, 140154466, 160645367, 162226561, 162817550, 172829375, 179293231, 184582401, 226478367, 242081676
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| ChEBI ID |
CHEBI:67237
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [2] |
| Oxysterols receptor LXR-alpha (NR1H3) | Target Info | Agonist | [3] | |
| Oxysterols receptor LXR-beta (NR1H2) | Target Info | Agonist | [3] | |
| KEGG Pathway | PPAR signaling pathway | |||
| Non-alcoholic fatty liver disease (NAFLD) | ||||
| Hepatitis C | ||||
| Bile secretion | ||||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| Recycling of bile acids and salts | ||||
| PPARA activates gene expression | ||||
| Endogenous sterols | ||||
| WikiPathways | SREBP signalling | |||
| Nuclear Receptors | ||||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Nuclear Receptors Meta-Pathway | ||||
| PPAR Alpha Pathway | ||||
| Liver X Receptor Pathway | ||||
| Adipogenesis | ||||
| SREBF and miR33 in cholesterol and lipid homeostasis | ||||
| Farnesoid X Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2742). | |||
| REF 2 | Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver ... J Pharmacol Exp Ther. 2006 Apr;317(1):317-25. | |||
| REF 3 | An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728-31. | |||
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