Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0KV4G
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| Former ID |
DNC010257
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| Drug Name |
1-(piperazin-1-yl)isoquinoline
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| Synonyms |
1-(piperazin-1-yl)isoquinoline; 126653-00-7; 1-Piperazine-1-yl-isoquinoline; 1-Piperazin-1-yl-isoquinoline; 1-(1-isoquinolinyl)piperazine; 1-(1-piperazinyl)isoquinoline; CHEMBL595552; Isoquinoline,1-(1-piperazinyl)-; Isoquinoline, 1-(1-piperazinyl)-; W-205253; 1-[1-Piperazinyl]isoquinoline; PubChem8306; ACMC-209ymu; piperazinohydroisoquinoline; 1-piperazin-1-ylisoquinoline; 1-Pyperazin-1-yl-isoquinoline; SCHEMBL2076366; TPC-A003; 1-(Isoquinolin-1-yl)piperazine; CTK4B5291; KS-00000JYY; IDFYLSABDUMICK-UHFFFAOYSA-N
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C13H15N3
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| Canonical SMILES |
C1CN(CCN1)C2=NC=CC3=CC=CC=C32
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| InChI |
1S/C13H15N3/c1-2-4-12-11(3-1)5-6-15-13(12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
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| InChIKey |
IDFYLSABDUMICK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2C receptor (HTR2C) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. | |||
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