Drug Information
Drug General Information | Top | |||
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Drug ID |
D0LR8X
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Former ID |
DIB020955
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Drug Name |
SKF-83556
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Synonyms |
SK-83566; SK&F-83566
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C17H18BrNO
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Canonical SMILES |
CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Br
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InChI |
1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
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InChIKey |
XFTVOHWWEQGXLS-UHFFFAOYSA-N
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CAS Number |
CAS 99295-33-7
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PubChem Compound ID | ||||
PubChem Substance ID |
5491588, 7980611, 8151057, 14777543, 24439588, 26752220, 47365430, 47440497, 47662526, 48110696, 50065403, 57320838, 75926542, 85787620, 103331797, 103808619, 103923120, 104297173, 117388470, 126407033, 129682574, 134223457, 135080025, 135651055, 163209974, 172649051, 179236225, 179447836, 250072303, 252559241
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ChEBI ID |
CHEBI:91747
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Target and Pathway | Top | |||
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Target(s) | Dopamine D1 receptor (D1R) | Target Info | Antagonist | [2] |
Dopamine D5 receptor (D5R) | Target Info | Antagonist | [2] | |
KEGG Pathway | Calcium signaling pathway | |||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Dopaminergic synapse | ||||
Gap junction | ||||
Parkinson's disease | ||||
Cocaine addiction | ||||
Amphetamine addiction | ||||
Morphine addiction | ||||
Alcoholism | ||||
Panther Pathway | Dopamine receptor mediated signaling pathway | |||
Pathwhiz Pathway | Dopamine Activation of Neurological Reward System | |||
Reactome | Dopamine receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Hypothetical Network for Drug Addiction | ||||
Genes and (Common) Pathways Underlying Drug Addiction |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 944). | |||
REF 2 | Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. |
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