Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0M4KE
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| Former ID |
DNC001093
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| Drug Name |
Parthenolide
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| Synonyms |
parthenolide; 20554-84-1; (-)-Parthenolide; CHEBI:7939; Parthenolide, Tanacetum parthenium; 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone; partenolide; C15H20O3; 29552-41-8; Prestwick2_000550; Prestwick3_000550; Epitope ID:115014; SCHEMBL8220; BSPBio_001308; BSPBio_000599; MLS002153872; CHEMBL465158; BPBio1_000659; SCHEMBL13367522; BCBcMAP01_000041; Parthenolide, > MolPort-008-268-168; MolPort-003-959-089; HMS1361B10; HMS3402B10; HMS1989B10; HMS1791B10; HMS1569N21; HMS2096N21
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H20O3
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| Canonical SMILES |
CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
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| InChI |
1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
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| InChIKey |
KTEXNACQROZXEV-PVLRGYAZSA-N
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| CAS Number |
CAS 20554-84-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12413771, 24278621, 24671467, 26756789, 26759317, 43064522, 47424978, 47424979, 47574105, 47721336, 47795785, 48244093, 48319197, 49699109, 50973094, 56463706, 57372321, 87246424, 92125565, 92309724, 99300638, 99302156, 103914300, 119503412, 119526028, 121363236, 123124679, 137023626, 140579898, 162187690, 163413395, 163687534, 163849138, 164196500, 175442100, 175607772, 184812409, 210280224, 210282203, 223394255, 223560388, 226399466, 238364679, 241038632, 242082896, 242084666, 249867955, 252068420, 252301908, 252455448
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| ChEBI ID |
CHEBI:7939
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol. 2001 Aug;8(8):759-66. | |||
| REF 2 | Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med. 2005 Jan 3;201(1):105-15. | |||
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