Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M6WW
|
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| Drug Name |
PMID30107136-Compound-Example11
|
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| Drug Type |
Small molecule immunotherapy
|
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| Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
ARISING INTERNATIONAL, INC
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C36H44N2O4
|
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| Canonical SMILES |
CC1=C(C=CC(=C1)CNCCO)OCC2=C(C(=CC=C2)C3=CC=CC(=C3C)COC4=C(C=C(C=C4)CNCCO)C)C
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| InChI |
1S/C36H44N2O4/c1-25-19-29(21-37-15-17-39)11-13-35(25)41-23-31-7-5-9-33(27(31)3)34-10-6-8-32(28(34)4)24-42-36-14-12-30(20-26(36)2)22-38-16-18-40/h5-14,19-20,37-40H,15-18,21-24H2,1-4H3
|
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| InChIKey |
OXBVQSJSNDTUEX-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CD80-PD-L1 interaction (CD80/PD-L1 PPI) | Target Info | Inhibitor | [1] |
| PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | CD80-PD-L1 interaction (CD80/PD-L1 PPI) | Target's Patent Info | [1] | |
| PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target's Patent Info | [1] | ||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. | |||
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