Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N4PL
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| Drug Name |
PMID29649907-Compound-36
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| Drug Type |
Small molecular drug
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| Company |
ALIOS BIOPHARMA, INC
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H23F2N3O3
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| Canonical SMILES |
CC(C)OC(=O)C1=CN(CC(C2=C1NC3=C2C=CC=N3)(C)C)C(=O)C4=CC(=C(C=C4)F)F
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| InChI |
1S/C24H23F2N3O3/c1-13(2)32-23(31)16-11-29(22(30)14-7-8-17(25)18(26)10-14)12-24(3,4)19-15-6-5-9-27-21(15)28-20(16)19/h5-11,13H,12H2,1-4H3,(H,27,28)
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| InChIKey |
PKWPSFIXOLFFPB-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
| Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
| KEGG Pathway | Bile secretion | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Recycling of bile acids and salts | |||
| PPARA activates gene expression | ||||
| Endogenous sterols | ||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| Nuclear Receptors Meta-Pathway | ||||
| Farnesoid X Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. | |||
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