Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N7HY
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| Former ID |
DIB020623
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| Drug Name |
Org 12962
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| Synonyms |
Org-12962; Org12962
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C10H11ClF3N3
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| Canonical SMILES |
C1CN(CCN1)C2=NC(=C(C=C2)C(F)(F)F)Cl
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| InChI |
1S/C10H11ClF3N3/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17/h1-2,15H,3-6H2
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| InChIKey |
QZYYPQAYSFBKPW-UHFFFAOYSA-N
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| CAS Number |
CAS 132834-56-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14848193, 24106295, 44832418, 50076970, 78818513, 85212004, 93816413, 103604038, 109620386, 124758392, 125432844, 126732500, 129099331, 134480425, 135580112, 135650777, 136351633, 137000416, 137144107, 139711519, 143471802, 160822611, 162049884, 162118603, 162301771, 162473604, 163382414, 165816001, 174546216, 187576417, 203092652, 223595679, 223657866, 227172108, 250203462, 252493275
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Agonist | [2] |
| 5-HT 2B receptor (HTR2B) | Target Info | Agonist | [2] | |
| 5-HT 2C receptor (HTR2C) | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Serotonin Receptor 2 and STAT3 Signaling | ||||
| SIDS Susceptibility Pathways | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 170). | |||
| REF 2 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. | |||
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