Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NY6P
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| Former ID |
DNC012695
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| Drug Name |
TEPA (possesses cytotoxic activity)
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| Synonyms |
TEPA; Triethylenephosphoramide; Aphoxide; 545-55-1; Tris(1-aziridinyl)phosphine oxide; TAPO; Imperon fixer T; Triaziridinophosphine oxide; Triethylenephosphorotriamide; Triaziridinylphosphine oxide; Triethylene phophoramide; Triethylene phosphoramide; Phosphoric acid triethylene imide; Tris(1-aziridine)phosphine oxide; Triethylenephosphoric triamide; ENT 24915; Tris(aziridinyl)phosphine oxide; Tri-1-aziridinylphosphine oxide; Triethylenepyrophosphoramide; Tri(aziridin-1-yl)phosphine oxide; TEPA (VAN)
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H12N3OP
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| Canonical SMILES |
C1CN1P(=O)(N2CC2)N3CC3
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| InChI |
1S/C6H12N3OP/c10-11(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
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| InChIKey |
FYAMXEPQQLNQDM-UHFFFAOYSA-N
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| CAS Number |
CAS 545-55-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:82546
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D1 receptor (D1R) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Dopaminergic synapse | ||||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Morphine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Dopamine receptor mediated signaling pathway | |||
| Pathwhiz Pathway | Dopamine Activation of Neurological Reward System | |||
| Reactome | Dopamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Genes and (Common) Pathways Underlying Drug Addiction | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies. J Med Chem. 1998 Oct 8;41(21):4165-70. | |||
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