Drug Information
Drug General Information | Top | |||
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Drug ID |
D0O0DF
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Former ID |
DIB004410
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Drug Name |
Lirequinil
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Synonyms |
Ro-41-3696
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Drug Type |
Small molecular drug
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Indication | Anxiety disorder [ICD-11: 6B00-6B0Z; ICD-10: R45.0] | Discontinued in Phase 2 | [1] | |
Company |
Roche Holding AG
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Structure |
Download2D MOL |
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Formula |
C26H25ClN2O3
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Canonical SMILES |
CCOC1CCN(C1)C(=O)C2=C3C4=C(CCN3C(=O)C(=C2)C5=CC=CC=C5)C=CC(=C4)Cl
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InChI |
1S/C26H25ClN2O3/c1-2-32-20-11-12-28(16-20)25(30)23-15-22(17-6-4-3-5-7-17)26(31)29-13-10-18-8-9-19(27)14-21(18)24(23)29/h3-9,14-15,20H,2,10-13,16H2,1H3/t20-/m0/s1
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InChIKey |
CBSWRAUYCIIUEI-FQEVSTJZSA-N
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CAS Number |
CAS 143943-73-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Translocator protein (TSPO) | Target Info | Agonist | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
HTLV-I infection |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001968) | |||
REF 2 | Pharmacokinetics and pharmacodynamics of Ro 41-3696, a novel nonbenzodiazepine hypnotic. J Clin Pharmacol. 1995 Aug;35(8):821-9. |
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