Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0OC3J
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| Former ID |
DAP000026
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| Drug Name |
Flupenthixol
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| Synonyms |
Depixol; Emergil; Fluanxol; Fluxanxol; Siplaril; Siplarol; LC 44; N 7009; ALPHA-FLUPENTHIXOL; Cis(Z)Flupenthixol; Cis-Flupenthixol; Cis-Flupentixol; Depixol (TN); Fluanxol (TN); Flupentixol (INN); Flupentixol [INN:DCF]; Flupentixolum [INN-Latin]; Cis-(Z)-Flupenthixol; (Z)-4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol; (Z)-4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazine-1-ethanol; 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-(9CI); 2-Trifluoromethyl-9-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propylidene)thioxanthene; 2-Trifluoromethyl-9-(3-(4-(beta-hydroxyethyl)-1-piperazinyl)propylidene)thioxanthene; 2-[4-[(3Z)-3-[2-(Trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol; 4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol; 4-(3-(2-(Trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethanol
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Withdrawn from market | [1], [2] | |
| Therapeutic Class |
Antipsychotic Agents
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| Company |
Lundbeck Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H25F3N2OS
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| Canonical SMILES |
C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO
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| InChI |
1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5-
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| InChIKey |
NJMYODHXAKYRHW-DVZOWYKESA-N
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| CAS Number |
CAS 53772-82-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13372, 651849, 7848107, 8616834, 14807748, 24262971, 26755684, 29216405, 39315468, 47515602, 47885671, 47960029, 48110746, 48185260, 48185261, 48259524, 49698443, 50013567, 50013569, 50111069, 50111070, 57358435, 77443886, 85209673, 85788350, 87225332, 90341514, 104098334, 113856122, 124749785, 124892370, 131279811, 134983857, 135002761, 135650273, 136351427, 137235935, 142970963, 144205556, 170465964, 179225419, 179236180, 198987516, 223441070, 226420710, 241093947, 250023293, 252347356, 252655887
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| ChEBI ID |
CHEBI:10454
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| SuperDrug ATC ID |
N05AF01
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| SuperDrug CAS ID |
cas=002709560
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 968). | |||
| REF 2 | Behavioral responses of dopamine beta-hydroxylase knockout mice to modafinil suggest a dual noradrenergic-dopaminergic mechanism of action. Pharmacol Biochem Behav. 2008 Dec;91(2):217-22. | |||
| REF 3 | A role for medial prefrontal dopaminergic innervation in instrumental conditioning. J Neurosci. 2009 May 20;29(20):6599-606. | |||
| REF 4 | Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. | |||
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