Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0OQ4H
|
|||
Former ID |
DIB014129
|
|||
Drug Name |
A-69024
|
|||
Synonyms |
A-69024; 58939-37-0; 7-Isoquinolinol, 1-((2-bromo-4,5-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6-methoxy-2-methyl-; A 69024; A-66359; A 66359; 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol; AC1L5ACF; 1-(2-Bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; Oprea1_293762; SCHEMBL462517; CTK1H3031
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Psychotic disorder [ICD-11: 6A20-6A25] | Terminated | [1] | |
Company |
Abbott Laboratories
|
|||
Structure |
Download2D MOL |
|||
Formula |
C20H24BrNO4
|
|||
Canonical SMILES |
CN1CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3Br)OC)OC)O)OC
|
|||
InChI |
1S/C20H24BrNO4/c1-22-6-5-12-8-18(24-2)17(23)10-14(12)16(22)7-13-9-19(25-3)20(26-4)11-15(13)21/h8-11,16,23H,5-7H2,1-4H3
|
|||
InChIKey |
YVBUTIYRCMQJHW-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 58939-37-0
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Dopamine D1 receptor (D1R) | Target Info | Modulator | [2] |
KEGG Pathway | Calcium signaling pathway | |||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Gap junction | ||||
Dopaminergic synapse | ||||
Parkinson's disease | ||||
Cocaine addiction | ||||
Amphetamine addiction | ||||
Morphine addiction | ||||
Alcoholism | ||||
Panther Pathway | Dopamine receptor mediated signaling pathway | |||
Pathwhiz Pathway | Dopamine Activation of Neurological Reward System | |||
Reactome | Dopamine receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Hypothetical Network for Drug Addiction | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
Genes and (Common) Pathways Underlying Drug Addiction | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002637) | |||
REF 2 | (+)-[76Br]A-69024: a non-benzazepine radioligand for studies of dopamine D1 receptors using PET. Nucl Med Biol. 2002 Apr;29(3):295-302. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.