Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0OZ4C
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| Former ID |
DNC003675
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| Drug Name |
6-Benzenesulfonyl-2H-pyridazin-3-one
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| Synonyms |
6-(benzenesulfonyl)-2,3-dihydropyridazin-3-one; 141060-78-8; 3(2H)-Pyridazinone, 6-(phenylsulfonyl)-; AC1Q6GZS; CHEMBL74814; SCHEMBL7295107; BDBM16442; ZICCKDUVBPQRQT-UHFFFAOYSA-N; MolPort-007-599-834; ZINC11536236; AKOS001782098; MCULE-8830355611; NE56517; 6-phenylsulfonylpyridazin-2H-3-one, 1; 6-phenylsulfonyl-3-oxo-2,3-dihydropyridazine; EN300-72670
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H8N2O3S
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| Canonical SMILES |
C1=CC=C(C=C1)S(=O)(=O)C2=NNC(=O)C=C2
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| InChI |
1S/C10H8N2O3S/c13-9-6-7-10(12-11-9)16(14,15)8-4-2-1-3-5-8/h1-7H,(H,11,13)
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| InChIKey |
ZICCKDUVBPQRQT-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aldose reductase (AKR1B1) | Target Info | Inhibitor | [1] |
| BioCyc | Methylglyoxal degradation III | |||
| Acetone degradation I (to methylglyoxal) | ||||
| KEGG Pathway | Pentose and glucuronate interconversions | |||
| Fructose and mannose metabolism | ||||
| Galactose metabolism | ||||
| Glycerolipid metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Fructose and Mannose Degradation | |||
| Pyruvate Metabolism | ||||
| Pterine Biosynthesis | ||||
| Glycerolipid Metabolism | ||||
| Galactose Metabolism | ||||
| WikiPathways | Metapathway biotransformation | |||
| Polyol Pathway | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. | |||
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