Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0P0SM
|
|||
Former ID |
DAP001345
|
|||
Drug Name |
Almogran
|
|||
Synonyms |
Almotriptan; Axert; Almotriptan (USAN); Axert (TN); LAS-31416; PNU-180638; Almotriptan [USAN:INN:BAN]; N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine; N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine; 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Approved | [1] | |
Therapeutic Class |
Antimigraine Agents
|
|||
Company |
Almirall Prodesfarma
|
|||
Structure |
Download2D MOL |
|||
Formula |
C17H25N3O2S
|
|||
Canonical SMILES |
CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3
|
|||
InChI |
1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3
|
|||
InChIKey |
WKEMJKQOLOHJLZ-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 154323-57-6
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
7300482, 7978664, 10240796, 11364820, 11367382, 11369944, 11372050, 11374785, 11378112, 11484131, 11488314, 11490821, 11492948, 11495698, 12014867, 14777713, 17396981, 26612825, 26680282, 26748976, 26748977, 29303840, 46505165, 47440551, 47515591, 50064504, 50107500, 76272137, 85174239, 85209556, 85709739, 85789661, 92124797, 93166206, 103558372, 104418894, 124637404, 125001916, 125341853, 126626719, 126659504, 126667010, 129593465, 131300220, 134222004, 134337533, 134338559, 135078946, 137002443, 142613257
|
|||
ChEBI ID |
CHEBI:520985
|
|||
ADReCS Drug ID | BADD_D00077 ; BADD_D00078 | |||
SuperDrug ATC ID |
N02CC05
|
|||
SuperDrug CAS ID |
cas=154323576
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | 5-HT 1D receptor (HTR1D) | Target Info | Agonist | [2] |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Serotonergic synapse | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
5HT1 type receptor mediated signaling pathway | ||||
Reactome | Serotonin receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | Drug information of Almogran, 2008. eduDrugs. | |||
REF 2 | Efficacy and tolerability of subcutaneous almotriptan for the treatment of acute migraine: a randomized, double-blind, parallel-group, dose-finding study. Clin Ther. 2001 Nov;23(11):1867-75. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.