Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0P8JA
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| Former ID |
DNC003597
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| Drug Name |
Ro-04-6790
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| Synonyms |
Ro 04-6790; 202466-68-0; Ro-04-6790; CHEMBL433461; Ro-046790; 4-amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide; 4-Amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide; 4-amino-N-(2,6-bis(methylamino)pyrimidin-4-yl)benzenesulfonamide; JELFWSXQTXRMAJ-UHFFFAOYSA-N; Ro 4-6790; NCGC00015885-01; 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide Dihydrobromide; Lopac-R-140; AC1NSM3L; Biomol-NT_000164; Lopac0_001045; GTPL274; SCHEMBL678897; BPBio1_000551; CTK8E8508; CHEBI:92762; ZINC23472
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H16N6O2S
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| Canonical SMILES |
CNC1=CC(=NC(=N1)NC)NS(=O)(=O)C2=CC=C(C=C2)N
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| InChI |
1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18)
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| InChIKey |
JELFWSXQTXRMAJ-UHFFFAOYSA-N
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| CAS Number |
CAS 202466-68-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7980531, 11056903, 11111728, 12015219, 14752063, 26755720, 39341763, 47721695, 47870812, 48095630, 48244483, 48244484, 50111226, 53092140, 57359528, 85209259, 85787460, 90340990, 99381440, 103230014, 103989000, 114157993, 124750194, 124881320, 124881321, 128263141, 134340802, 135650909, 135698492, 140775890, 141679203, 163123420, 179235839, 204360712, 225053443, 226973665, 241376163, 242242309, 249617709, 251963225, 252156869
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| ChEBI ID |
CHEBI:92762
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 6 receptor (HTR6) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | |||
| Reactome | Serotonin receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 274). | |||
| REF 2 | Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. J Med Chem. 2009 Feb 12;52(3):675-87. | |||
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