Drug Information
Drug General Information | Top | |||
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Drug ID |
D0P9PZ
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Drug Name |
PMID25980951-Compound-10
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Drug Type |
Small molecular drug
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Company |
GENENTECH, INC. BERGERON, Philippe KOEHLER, Michael, F. T
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Structure |
Download2D MOL |
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Formula |
C28H35N5O3
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Canonical SMILES |
CC(C(=O)NC(C1CCOCC1)C(=O)N2CCCC2C3=CC4=C(N3)C(=NC=C4)C5=CC=CC=C5)NC
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InChI |
1S/C28H35N5O3/c1-18(29-2)27(34)32-26(20-11-15-36-16-12-20)28(35)33-14-6-9-23(33)22-17-21-10-13-30-24(25(21)31-22)19-7-4-3-5-8-19/h3-5,7-8,10,13,17-18,20,23,26,29,31H,6,9,11-12,14-16H2,1-2H3,(H,32,34)/t18-,23-,26-/m0/s1
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InChIKey |
IKVUPSWUHVVHKV-WMDMVVLCSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | X-linked inhibitor of apoptosis protein (XIAP) | Target Info | Antagonist | [1] |
Target's Patent Info | X-linked inhibitor of apoptosis protein (XIAP) | Target's Patent Info | [1] | |
KEGG Pathway | NF-kappa B signaling pathway | |||
Ubiquitin mediated proteolysis | ||||
Apoptosis | ||||
Focal adhesion | ||||
Toxoplasmosis | ||||
HTLV-I infection | ||||
Pathways in cancer | ||||
Small cell lung cancer | ||||
Panther Pathway | Apoptosis signaling pathway | |||
Pathway Interaction Database | p75(NTR)-mediated signaling | |||
BMP receptor signaling | ||||
Caspase Cascade in Apoptosis | ||||
TGF-beta receptor signaling | ||||
Reactome | SMAC binds to IAPs | |||
SMAC-mediated dissociation of IAP:caspase complexes | ||||
Deactivation of the beta-catenin transactivating complex | ||||
RIPK1-mediated regulated necrosis | ||||
Regulation of TNFR1 signaling | ||||
TNFR1-induced NFkappaB signaling pathway | ||||
Regulation of necroptotic cell death | ||||
WikiPathways | Copper homeostasis | |||
Focal Adhesion | ||||
Apoptosis | ||||
Intrinsic Pathway for Apoptosis | ||||
Apoptosis Modulation and Signaling | ||||
NOD pathway |
References | Top | |||
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REF 1 | Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. |
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