Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Q2SI
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| Former ID |
DNC013020
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| Drug Name |
4-(4-chlorobenzyl)phthalazin-1(2H)-one
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| Synonyms |
53242-88-9; 4-(4-chlorobenzyl)phthalazin-1(2H)-one; 4-(4-Chloro-benzyl)-2H-phthalazin-1-one; 4-[(4-chlorophenyl)methyl]-2H-phthalazin-1-one; UNII-56DW142LLX; MLS000547504; 4-(4-chlorobenzyl)phthalazin-1-ol; CHEMBL63976; 4-(4-chlorobenzyl)-1(2H)-phthalazinone; 56DW142LLX; 4-[(4-CHLOROPHENYL)METHYL]PHTHALAZIN-1(2H)-ONE; SMR000113649; 4-(4-Chlorobenzyl)-2H-phthalazin-1-one; 4-[(4-Chlorophenyl)methyl]-1(2H)-phthalazinone; 4-((4-Chlorophenyl)methyl)phthalazin-1(2H)-one; W-109042; 4-{[4-chlorophenyl]methyl}-1(2H)-phthalazinone
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C15H11ClN2O
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=NNC2=O)CC3=CC=C(C=C3)Cl
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| InChI |
1S/C15H11ClN2O/c16-11-7-5-10(6-8-11)9-14-12-3-1-2-4-13(12)15(19)18-17-14/h1-8H,9H2,(H,18,19)
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| InChIKey |
NLXGCQIEVZYDRS-UHFFFAOYSA-N
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| CAS Number |
CAS 53242-88-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-1A (ADRA1A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-1D (ADRA1D) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Vascular smooth muscle contraction | ||||
| Salivary secretion | ||||
| AMPK signaling pathway | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Reactome | Adrenoceptors | |||
| G alpha (q) signalling events | ||||
| G alpha (12/13) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| Endothelin Pathways | ||||
| AMPK Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. | |||
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