Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0QH0X
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| Former ID |
DNC012476
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| Drug Name |
2,3,4,5-Tetrahydro-1H-benzo[c]azepine
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| Synonyms |
2,3,4,5-Tetrahydro-1H-benzo[c]azepine; 7216-22-0; 2,3,4,5-tetrahydro-1H-2-benzazepine; 1H-2-Benzazepine, 2,3,4,5-tetrahydro-; CHEMBL118310; SCHEMBL233066; ARK042; CTK2H2810; DTXSID00440260; SIQBPWRTJNBBER-UHFFFAOYSA-N; MolPort-020-016-004; BDBM50052883; ANW-49031; ZINC13516868; AKOS005264678; MCULE-2809792553; AB49623; 2,3,4,5-tetrahydro 1H-2-benzazepine; BS-13541; BR-76361; AJ-64016; TC-137776; DB-074526; W8089; ST24021451; FT-0707305; 4CH-000440; S-5095; 2,3,4,5-tetrahydro-1H-benzo[c]azepine, AldrichCPR
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H13N
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| Canonical SMILES |
C1CC2=CC=CC=C2CNC1
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| InChI |
1S/C10H13N/c1-2-5-10-8-11-7-3-6-9(10)4-1/h1-2,4-5,11H,3,6-8H2
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| InChIKey |
SIQBPWRTJNBBER-UHFFFAOYSA-N
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| CAS Number |
CAS 7216-22-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Integration of energy metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. | |||
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