Drug Information
Drug General Information | Top | |||
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Drug ID |
D0QO8X
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Former ID |
DNC012793
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Drug Name |
1,2,3,4-Tetrahydro-isoquinolin-7-ol
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Synonyms |
1,2,3,4-tetrahydroisoquinolin-7-ol; 30798-64-2; 1,2,3,4-Tetrahydro-isoquinolin-7-ol; 1,2,3,4-Tetrahydro-7-isoquinolinol; 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline; CHEMBL27730; RADQTHXRZJGDQI-UHFFFAOYSA-N; 7-Isoquinolinol, 1,2,3,4-tetrahydro-; 1,2,3,4-Tetrahydro-iosquinoline-7-ol; AC1L9HE2; 7-Hydroxytetrahydroisochinolin; SCHEMBL470826; AC1Q798F; DTXSID40329303; MolPort-005-312-666; ZINC3847389; BDBM50024826; ANW-75301; AKOS006222928; MB05747; RP21285; AC-9597; MCULE-2692939705; KB-74165; KB-64192; BS-13490; AJ-45863; TC-062003
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C9H11NO
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Canonical SMILES |
C1CNCC2=C1C=CC(=C2)O
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InChI |
1S/C9H11NO/c11-9-2-1-7-3-4-10-6-8(7)5-9/h1-2,5,10-11H,3-4,6H2
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InChIKey |
RADQTHXRZJGDQI-UHFFFAOYSA-N
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CAS Number |
CAS 30798-64-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
KEGG Pathway | cGMP-PKG signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Reactome | Adrenoceptors | |||
Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
Adrenaline,noradrenaline inhibits insulin secretion | ||||
G alpha (i) signalling events | ||||
G alpha (z) signalling events | ||||
Surfactant metabolism | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
Platelet Aggregation (Plug Formation) | ||||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. |
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