Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R1ER
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| Former ID |
DNC011986
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| Drug Name |
2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one
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| Synonyms |
CHEMBL3144574; CHEMBL8374; 2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one; BDBM50009014
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H13N3O
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=CN2)CN3C(=O)C4=CC=CC=C4N3
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| InChI |
1S/C16H13N3O/c20-16-13-6-2-4-8-15(13)18-19(16)10-11-9-17-14-7-3-1-5-12(11)14/h1-9,17-18H,10H2
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| InChIKey |
IAJFPXRONWWXNK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 5-lipoxygenase (5-LOX) | Target Info | Inhibitor | [1] |
| BioCyc | Aspirin-triggered lipoxin biosynthesis | |||
| Resolvin D biosynthesis | ||||
| Leukotriene biosynthesis | ||||
| Lipoxin biosynthesis | ||||
| Aspirin triggered resolvin D biosynthesis | ||||
| Aspirin triggered resolvin E biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Ovarian steroidogenesis | ||||
| Toxoplasmosis | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. | |||
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