Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R2YM
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| Former ID |
DNC011469
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| Drug Name |
5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine
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| Synonyms |
CHEMBL123566; 5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine; BDBM50002150; 143591-65-5; 5-Bromo-8-(1-piperazinyl)imidazo[1,2-a]pyrazine; Imidazo[1,2-a]pyrazine, 5-bromo-8-(1-piperazinyl)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H12BrN5
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| Canonical SMILES |
C1CN(CCN1)C2=NC=C(N3C2=NC=C3)Br
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| InChI |
1S/C10H12BrN5/c11-8-7-14-9(10-13-3-6-16(8)10)15-4-1-12-2-5-15/h3,6-7,12H,1-2,4-5H2
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| InChIKey |
SOIWQJOBNCOQPP-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-1A (ADRA1A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-1D (ADRA1D) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Vascular smooth muscle contraction | ||||
| Salivary secretion | ||||
| AMPK signaling pathway | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Reactome | Adrenoceptors | |||
| G alpha (q) signalling events | ||||
| G alpha (12/13) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| Endothelin Pathways | ||||
| AMPK Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. J Med Chem. 1992 Oct 16;35(21):3845-57. | |||
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