Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0R4CX
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| Drug Name |
US9409892, 59
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| Synonyms |
SCHEMBL15268697; CHEMBL3893917; QBSUFMQXFVGWJT-UHFFFAOYSA-N; BDBM240964; US9409892, 59; 3-{[1-Cyano-4-hydroxy-7-(naphthalen-2-yloxy)-isoquinoline-3-carbonyl]-amino}-2,2-dimethyl-propionic acid
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C26H21N3O5
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| Canonical SMILES |
CC(C)(CNC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC4=CC=CC=C4C=C3)C(=N1)C#N)O)C(=O)O
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| InChI |
1S/C26H21N3O5/c1-26(2,25(32)33)14-28-24(31)22-23(30)19-10-9-18(12-20(19)21(13-27)29-22)34-17-8-7-15-5-3-4-6-16(15)11-17/h3-12,30H,14H2,1-2H3,(H,28,31)(H,32,33)
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| InChIKey |
QBSUFMQXFVGWJT-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
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| REF 1 | 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892. | |||
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