Drug Information
Drug General Information | Top | |||
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Drug ID |
D0RZ0N
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Former ID |
DIB010341
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Drug Name |
FR-62765
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Synonyms |
FR-62765; 105346-34-7; FR 62765; ODHJHYPKZNTPCS-UHFFFAOYSA-N; AC1L2TN6; SCHEMBL5953715; Ethyl 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-2-furanpropanoate; ethyl 3-(4-methoxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoate; ethyl 3-(4-methoxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)propionate; 2-Furanpropanoic acid, 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-, ethyl ester
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Drug Type |
Small molecular drug
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Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Terminated | [1] | |
Company |
Fujisawa Pharmaceutical Co Ltd
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Structure |
Download2D MOL |
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Formula |
C16H18O5
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Canonical SMILES |
CCOC(=O)CCC1C(=C(C(=O)O1)OC)C2=CC=CC=C2
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InChI |
1S/C16H18O5/c1-3-20-13(17)10-9-12-14(11-7-5-4-6-8-11)15(19-2)16(18)21-12/h4-8,12H,3,9-10H2,1-2H3
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InChIKey |
ODHJHYPKZNTPCS-UHFFFAOYSA-N
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CAS Number |
CAS 105346-34-7
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Aldose reductase (AKR1B1) | Target Info | Modulator | [1] |
BioCyc | Methylglyoxal degradation III | |||
Acetone degradation I (to methylglyoxal) | ||||
KEGG Pathway | Pentose and glucuronate interconversions | |||
Fructose and mannose metabolism | ||||
Galactose metabolism | ||||
Glycerolipid metabolism | ||||
Metabolic pathways | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Pathwhiz Pathway | Fructose and Mannose Degradation | |||
Pyruvate Metabolism | ||||
Pterine Biosynthesis | ||||
Glycerolipid Metabolism | ||||
Galactose Metabolism | ||||
WikiPathways | Metapathway biotransformation | |||
Polyol Pathway | ||||
Metabolism of steroid hormones and vitamin D |
References | Top | |||
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REF 1 | Studies on WF-3681, a novel aldose reductase inhibitor. IV. Effect of FR-62765, a derivative of WF-3681, on the diabetic neuropathy in rats. J Antibiot (Tokyo). 1991 Apr;44(4):441-4. |
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