Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S4DT
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| Former ID |
DIB021159
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| Drug Name |
vinburnine
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| Synonyms |
eburnamonine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C19H22N2O
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| Canonical SMILES |
CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=O)C2
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| InChI |
1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1
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| InChIKey |
WYJAPUKIYAZSEM-MOPGFXCFSA-N
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| CAS Number |
CAS 4880-88-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11341, 457665, 8141186, 8149858, 8194490, 10321289, 11335586, 11360825, 11363273, 11365835, 11368397, 11372476, 11374241, 11376559, 11407193, 11458362, 11460274, 11461797, 11466635, 11467755, 11485283, 11486469, 11489320, 11491014, 11492566, 11494193, 14898141, 16085526, 26652298, 26680063, 29204089, 43127578, 47216711, 47440186, 47515255, 47588935, 47959666, 47959667, 48035041, 48110392, 48184937, 49698581, 50063097, 50957982, 56463657, 57318066, 61212461, 85787855, 85789394, 88785574
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| ChEBI ID |
CHEBI:4740
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Eburnamonine (-) (adjusted p-values: 2.90E-03). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 345). | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. | |||
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