Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S4MN
|
|||
| Former ID |
DIB021155
|
|||
| Drug Name |
veratridine
|
|||
| Synonyms |
veratrine; 3-veratroylveracevine
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C36H51NO11
|
|||
| Canonical SMILES |
CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O
|
|||
| InChI |
1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
|
|||
| InChIKey |
FVECELJHCSPHKY-YFUMOZOISA-N
|
|||
| CAS Number |
CAS 71-62-5
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
8137895, 11445999, 43526946, 46530453, 48393489, 50062968, 50111382, 53788722, 78684425, 85788256, 85856318, 92309931, 99300845, 103072066, 103081921, 104045143, 104311613, 134972303, 135652724, 136046139, 137005967, 175607798, 184582578, 194154853, 198983944, 226433616, 241376167, 249583246, 252156874, 252402715, 252455655
|
|||
| ChEBI ID |
CHEBI:28051
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | SCN1A messenger RNA (SCN1A mRNA) | Target Info | Activator | [2] |
| Voltage-gated sodium channel alpha Nav1.2 (SCN2A) | Target Info | Activator | [3] | |
| Voltage-gated sodium channel alpha Nav1.3 (SCN3A) | Target Info | Activator | [4] | |
| Voltage-gated sodium channel alpha Nav1.4 (SCN4A) | Target Info | Activator | [5] | |
| Voltage-gated sodium channel alpha Nav1.5 (SCN5A) | Target Info | Activator | [6] | |
| Voltage-gated sodium channel alpha Nav1.6 (SCN8A) | Target Info | Activator | [7] | |
| Voltage-gated sodium channel alpha Nav1.7 (SCN9A) | Target Info | Activator | [8] | |
| Voltage-gated sodium channel alpha Nav1.8 (SCN10A) | Target Info | Activator | [9] | |
| KEGG Pathway | Dopaminergic synapse | |||
| Adrenergic signaling in cardiomyocytes | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Cardiac Progenitor Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2626). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 578). | |||
| REF 3 | Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. J Biol Chem. 1981 Sep 10;256(17):8922-7. | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580). | |||
| REF 5 | Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8. | |||
| REF 6 | Sodium channel comodification with full activator reveals veratridine reaction dynamics. Mol Pharmacol. 1990 Feb;37(2):144-8. | |||
| REF 7 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583). | |||
| REF 8 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584). | |||
| REF 9 | A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglio... Pflugers Arch. 2008 Feb;455(5):929-38. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.