Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S5FQ
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| Former ID |
DIB000104
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| Drug Name |
MCPP
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| Synonyms |
1-(3-Chlorophenyl)piperazine
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| Drug Type |
Small molecular drug
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| Indication | Mood disorder [ICD-11: 6A60-6E23] | Discontinued in Phase 2 | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C10H11ClO3
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| Canonical SMILES |
CC1=C(C=CC(=C1)Cl)OC(C)C(=O)O
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| InChI |
1S/C10H11ClO3/c1-6-5-8(11)3-4-9(6)14-7(2)10(12)13/h3-5,7H,1-2H3,(H,12,13)
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| InChIKey |
WNTGYJSOUMFZEP-UHFFFAOYSA-N
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| CAS Number |
CAS 93-65-2
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:75704
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2C receptor (HTR2C) | Target Info | Agonist | [2], [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats. Br J Pharmacol. 2011 Apr;162(8):1770-80. | |||
| REF 2 | mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes. Neuropharmacology. 2004 Apr;46(5):663-71. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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