Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0SA4A
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| Former ID |
DIB020331
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| Drug Name |
meta-chlorphenylbiguanide
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| Synonyms |
m-Chlorophenylbiguanide; mCPBG; 1-(3-Chlorophenyl)biguanide; 1-(m-Chlorophenyl)biguanide; N-(3-Chlorophenyl)imidodicarbonimidic diamide; 48144-44-1; Imidodicarbonimidic diamide, N-(3-chlorophenyl)-; UNII-910A4X901V; M-Chlorophenylbiguanidine; 3-Chloro-Phenyl biguanide; 2-(3-chlorophenyl)-1-(diaminomethylidene)guanidine; CHEMBL13790; CHEBI:32347; N-(3-chlorophenyl)-N'-(diaminomethylene)guanidine; 910A4X901V; C8H10ClN5; Imidodicarbonimidicdiamide, N-(3-chlorophenyl)-; 1-carbamimidamido-N-(3-chlorophenyl)methanimidamide; 1-(3-chlorophenyl)biguanide; m-chlorophenylbiguanide; 3-chlorophenyl-biguanide; [3H]meta-chlorophenylbiguanide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C8H10ClN5
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| Canonical SMILES |
C1=CC(=CC(=C1)Cl)N=C(N)N=C(N)N
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| InChI |
1S/C8H10ClN5/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)
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| InChIKey |
DIHXJZHAIHGSAW-UHFFFAOYSA-N
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| CAS Number |
CAS 48144-44-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
586256, 5286670, 7223051, 7941910, 7978566, 11110885, 11113502, 15220229, 24439695, 26751722, 47440465, 47662501, 48185177, 50064808, 50104412, 53837813, 57320880, 57756207, 59801931, 75031824, 81093350, 85787814, 87967146, 89578907, 90340725, 103176250, 103826501, 103950294, 104297494, 106772062, 107893064, 117460323, 117524446, 117832248, 118370216, 124749636, 124879493, 124879494, 124879495, 125668006, 127738970, 135071978, 135650380, 135651162, 136350445, 137129162, 137147747, 137230980, 139625845, 162220869
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| ChEBI ID |
CHEBI:32347
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3A receptor (HTR3A) | Target Info | Agonist | [3] |
| 5-HT 3B receptor (HTR3B) | Target Info | Agonist | [4] | |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | 5HT3 type receptor mediated signaling pathway | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2304). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2287). | |||
| REF 3 | Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br J Pharmacol. 1998 Feb;123(4):661-6. | |||
| REF 4 | Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4. | |||
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