Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SM8Z
|
|||
| Drug Name |
US9409892, 148
|
|||
| Synonyms |
CHEMBL3893184; SCHEMBL15268628; BDBM241053; US9409892, 148
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H17FN2O4
|
|||
| Canonical SMILES |
C1=CC(=CC=C1C2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCC(=O)O)F
|
|||
| InChI |
1S/C20H17FN2O4/c21-15-6-3-12(4-7-15)13-5-8-16-14(10-13)11-23-18(19(16)26)20(27)22-9-1-2-17(24)25/h3-8,10-11,26H,1-2,9H2,(H,22,27)(H,24,25)
|
|||
| InChIKey |
ZCPXHSRUGVQBOS-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.