Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T1YO
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| Former ID |
DNC011366
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| Drug Name |
GNF-PF-2307
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| Synonyms |
3-Phenyl-5H-indeno[1,2-c]pyridazin-5-one; GNF-PF-2307; NSC663883; 77152-22-8; CHEMBL421088; 3-phenylindeno[1,2-c]pyridazin-5-one; 5H-Indeno[1,2-c]pyridazin-5-one, 3-phenyl-; AC1Q6KMU; AC1L8E6X; Oprea1_571099; MLS000539984; cid_379337; Aza-heterocyclic Derivative, 1b; KS-00001QSP; CTK2G0333; BDBM19164; DTXSID40327521; MolPort-002-851-051; HMS2177H12; ZINC1383534; STK336084; AKOS005075114; NSC-663883; MCULE-8078785196; SMR000125442; NCI60_021916; 3-(Phenyl)-5H-indeno[1,2-c]pyridazin-5-one; SR-01000694335; 10K-057
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H10N2O
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NN=C3C4=CC=CC=C4C(=O)C3=C2
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| InChI |
1S/C17H10N2O/c20-17-13-9-5-4-8-12(13)16-14(17)10-15(18-19-16)11-6-2-1-3-7-11/h1-10H
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| InChIKey |
ORLUBUYLVCUFDE-UHFFFAOYSA-N
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| CAS Number |
CAS 77152-22-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin II receptor type-1 (AGTR1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Vascular smooth muscle contraction | ||||
| Renin-angiotensin system | ||||
| Renin secretion | ||||
| Pathways in cancer | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Panther Pathway | Angiotensin II-stimulated signaling through G proteins and beta-arrestin | |||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Muscle/Heart Contraction | ||||
| Pathway Interaction Database | Arf6 trafficking events | |||
| Arf6 signaling events | ||||
| Angiopoietin receptor Tie2-mediated signaling | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | ACE Inhibitor Pathway | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| Allograft Rejection | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | |||
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