Drug Information
Drug General Information | Top | |||
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Drug ID |
D0T3JW
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Former ID |
DCL001028
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Drug Name |
U-99194A
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Synonyms |
U 99194A; (5,6-dimethoxyindan-2-yl)dipropylamine; 1H-Indan-2-amine, 2,3-dihydro-5,6-dimethoxy-N,N-dipropyl-, hydrochloride; 1H-Inden-2-amine, 2,3-dihydro-5,6-dimethoxy-N,N-dipropyl-, hydrochloride; 5,6-Dimethoxy-2-(dipropylamino)indan hydrochloride; 5,6-Dimethoxy-N,N-dipropyl-2,3-dihydro-1H-indan-2-amine; 5,6-Dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine hydrochloride; 5,6-dimethoxy-2-(di-n-propylamino)indan; 5,6-dimethoxy-n,n-dipropyl-2,3-dihydro-1h-inden-2-amine hydrochloride(1:1)
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Drug Type |
Small molecular drug
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Indication | Schizophrenia [ICD-11: 6A20] | Preclinical | [1] | |
Company |
Pfizer
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Structure |
Download2D MOL |
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Formula |
C17H28ClNO2
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Canonical SMILES |
CCCN(CCC)C1CC2=CC(=C(C=C2C1)OC)OC.Cl
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InChI |
1S/C17H27NO2.ClH/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;/h11-12,15H,5-10H2,1-4H3;1H
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InChIKey |
NMBUOXDBNWBGIM-UHFFFAOYSA-N
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CAS Number |
CAS 83598-46-3
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
SuperDrug ATC ID |
H01BA02
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SuperDrug CAS ID |
cas=016679586
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Target and Pathway | Top | |||
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Target(s) | Dopamine D3 receptor (D3R) | Target Info | Binder | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Dopaminergic synapse | ||||
Reactome | Dopamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Nicotine Activity on Dopaminergic Neurons | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. |
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