Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T4PS
|
|||
| Former ID |
DIB020261
|
|||
| Drug Name |
LY 165,163
|
|||
| Synonyms |
PAPP; LY-165163
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C19H22F3N3
|
|||
| Canonical SMILES |
C1CN(CCN1CCC2=CC=C(C=C2)N)C3=CC=CC(=C3)C(F)(F)F
|
|||
| InChI |
1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2
|
|||
| InChIKey |
GAAKALASJNGQKD-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 1814-64-8
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
795222, 6333886, 10239871, 11111756, 11413468, 15250266, 17405688, 24262978, 24278123, 26753653, 29302422, 46500433, 47589251, 47736779, 48334801, 50064554, 50107046, 50107047, 50904843, 53778238, 57339852, 85231213, 85788318, 90340652, 92303251, 103132653, 104414628, 117505147, 121361829, 123098328, 124750259, 124800165, 124881355, 124881356, 125543477, 127924210, 135076448, 135650543, 162227434, 163110011, 163565086, 178125578, 179235765, 198973003, 229944590
|
|||
| ChEBI ID |
CHEBI:92250
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Agonist | [2] |
| 5-HT 6 receptor (HTR6) | Target Info | Agonist | [3] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Calcium signaling pathway | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | |||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 18). | |||
| REF 2 | Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. | |||
| REF 3 | Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.