Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T7RY
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| Former ID |
DNC008398
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| Drug Name |
6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine
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| Synonyms |
6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine; CHEMBL262862; 180160-89-8; SCHEMBL7885461; WMCWIMZEYWNBOQ-UHFFFAOYSA-N; BDBM50375903; L021806
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H11Cl2N
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| Canonical SMILES |
C1CNCCC2=C1C=CC(=C2Cl)Cl
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| InChI |
1S/C10H11Cl2N/c11-9-2-1-7-3-5-13-6-4-8(7)10(9)12/h1-2,13H,3-6H2
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| InChIKey |
WMCWIMZEYWNBOQ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
| 5-HT 2B receptor (HTR2B) | Target Info | Inhibitor | [1] | |
| 5-HT 2C receptor (HTR2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Serotonin Receptor 2 and STAT3 Signaling | ||||
| SIDS Susceptibility Pathways | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. | |||
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