Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0TG0I
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| Former ID |
DNC005948
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| Drug Name |
1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-indole
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| Synonyms |
CHEMBL370779; 1-(phenylsulfonyl)-4-(1-piperazinyl)-1h-indole; 1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-indole; 412049-71-9; 1-Benzenesulfonyl-4-piperazin-1-yl-1H-indole; SCHEMBL1136504; ZINC3210; DTXSID90436238; OPAMDWUUNKYGOR-UHFFFAOYSA-N; BDBM50174269; 1-(phenylsulfonyl)-4-piperazin-1-yl-indole; FT-0724295; 1-(benzenesulfonyl)-4-(1-piperazinyl)indole; 1-(phenylsulfonyl)-4-piperzin-1-yl-1H-indole; 1-(phenylsulfonyl)-4-piperazin-1-yl-1H-indole; 1-(phenylsulfonyl)-4-piperazin-1-y1-1H-indole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C18H19N3O2S
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| Canonical SMILES |
C1CN(CCN1)C2=CC=CC3=C2C=CN3S(=O)(=O)C4=CC=CC=C4
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| InChI |
1S/C18H19N3O2S/c22-24(23,15-5-2-1-3-6-15)21-12-9-16-17(7-4-8-18(16)21)20-13-10-19-11-14-20/h1-9,12,19H,10-11,13-14H2
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| InChIKey |
OPAMDWUUNKYGOR-UHFFFAOYSA-N
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| CAS Number |
CAS 412049-71-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 6 receptor (HTR6) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | |||
| Reactome | Serotonin receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. | |||
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