Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0TH8D
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| Former ID |
DNC012242
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| Drug Name |
8-Methoxy-2-piperazin-1-yl-quinoline
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| Synonyms |
8-Methoxy-2-piperazin-1-yl-quinoline; CHEMBL80691; Quinoline, 8-methoxy-2-(1-piperazinyl)-; 104090-79-1; 8-Methoxyquipazine; ACMC-20m6vj; SCHEMBL6767019; CTK0G6599; DTXSID30627183; CUULVNAZRYFNIT-UHFFFAOYSA-N; ZINC26467647; BDBM50025465; AKOS022401904
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C14H17N3O
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| Canonical SMILES |
COC1=CC=CC2=C1N=C(C=C2)N3CCNCC3
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| InChI |
1S/C14H17N3O/c1-18-12-4-2-3-11-5-6-13(16-14(11)12)17-9-7-15-8-10-17/h2-6,15H,7-10H2,1H3
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| InChIKey |
CUULVNAZRYFNIT-UHFFFAOYSA-N
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| CAS Number |
CAS 104090-79-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Inhibitor | [1] |
| 5-HT 1D receptor (HTR1D) | Target Info | Inhibitor | [1] | |
| 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Calcium signaling pathway | ||||
| Gap junction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| 5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Serotonin Receptor 2 and STAT3 Signaling | ||||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. | |||
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