Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0TN2R
|
|||
| Former ID |
DNC012106
|
|||
| Drug Name |
3-Methoxymethyl-1,2,3,4-tetrahydro-isoquinoline
|
|||
| Synonyms |
CHEMBL294562; Isoquinoline, 1,2,3,4-tetrahydro-3-(methoxymethyl)-; 245125-98-8; 3-Methoxymethyl-1,2,3,4-tetrahydro-isoquinoline; 3-(methoxymethyl)-1,2,3,4-tetrahydroisoquinoline; SCHEMBL7585285
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C11H15NO
|
|||
| Canonical SMILES |
COCC1CC2=CC=CC=C2CN1
|
|||
| InChI |
1S/C11H15NO/c1-13-8-11-6-9-4-2-3-5-10(9)7-12-11/h2-5,11-12H,6-8H2,1H3
|
|||
| InChIKey |
IDSUOIGUQHWCCU-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.