Drug Information
Drug General Information | Top | |||
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Drug ID |
D0TX8W
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Former ID |
DNC005949
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Drug Name |
4-(piperazin-1-yl)-1H-indole
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Synonyms |
4-(1-Piperazinyl)-1H-indole; 84807-09-0; 4-(piperazin-1-yl)-1H-indole; 4-Piperazino-1H-indole; 1H-Indole, 4-(1-piperazinyl)-; 4-(Piperazino)indole; 4-piperazin-1-yl-1H-indole; 1-(4-indolyl)piperazine; CHEMBL200234; YZKSXUIOKWQABW-UHFFFAOYSA-N; AK-26360; W-206959; 1H-Indole-4-(1-piperazinyl)dihydrochloride; 4-piperazinoindole; 4-piperazino-indole; PubChem22668; AC1LC5AN; 1H-indol-4-ylpiperazine; 4-(1-piperazinyl)indole; 1-(indol-4yl)piperazine; 1-(indol-4yl)-piperazine; 1-(indol-4-yl)piperazine; 1-(4-indolyl)-piperazine
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C12H15N3
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Canonical SMILES |
C1CN(CCN1)C2=CC=CC3=C2C=CN3
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InChI |
1S/C12H15N3/c1-2-11-10(4-5-14-11)12(3-1)15-8-6-13-7-9-15/h1-5,13-14H,6-9H2
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InChIKey |
YZKSXUIOKWQABW-UHFFFAOYSA-N
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CAS Number |
CAS 84807-09-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 6 receptor (HTR6) | Target Info | Inhibitor | [1] |
KEGG Pathway | Calcium signaling pathway | |||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Serotonergic synapse | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | |||
Reactome | Serotonin receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. |
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