Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U3EC
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| Former ID |
DAP000584
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| Drug Name |
Benazepril
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| Synonyms |
Benazapril; Benazeprilum; Benzazepril; Benazepril Sandoz; Benazeprilum [Latin]; Forteekor [veterinary]; Benazepril (INN); Benazepril Sandoz (TN); Benazepril [INN:BAN]; Forteekor [veterinary] (TN); Fortekor (TN); Lotensin (TN); CGS-14824-A; [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; [(3S)-3-({(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; [(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Norvatis Phamaceuticals Corporation
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| Structure |
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Download2D MOL |
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| Formula |
C24H28N2O5
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| Canonical SMILES |
CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O
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| InChI |
1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
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| InChIKey |
XPCFTKFZXHTYIP-PMACEKPBSA-N
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| CAS Number |
CAS 86541-75-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9061, 11364868, 11367430, 11369992, 11372806, 11373951, 11378161, 11484079, 11488298, 11491489, 11492101, 11495736, 11533499, 11654004, 14856184, 14880498, 29217496, 39384400, 46507884, 47291378, 47960005, 48415605, 49877926, 50111699, 50171976, 51091824, 53788310, 85787982, 93166958, 94568986, 103220490, 103931866, 114149713, 117871221, 124893187, 126663871, 127334967, 127334968, 127334969, 127334970, 127334971, 127334972, 127334973, 127334974, 127334975, 127334976, 127334977, 127334978, 129720750, 131328443
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| ChEBI ID |
CHEBI:3011
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| ADReCS Drug ID | BADD_D00227 ; BADD_D00228 | |||
| SuperDrug ATC ID |
C09AA07
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| SuperDrug CAS ID |
cas=086541755
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.415; p = 0.01). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.838; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.694; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.664; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.648; p = 0.017). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.552; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.566; p = 0.018). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.799; p = 0.0). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -0.411; p = 0.029). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -0.425; p = 0.009). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.467; p = 0.029). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.457; p = 0.008). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.565; p = 0.033). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.625; p = 0.008). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.587; p = 0.007). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.652; p = 0.015). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Odoribacter splanchnicus (log2FC = -0.413; p = 0.021). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.771; p = 0.048). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.322; p = 0.036). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.549; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benazepril can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.489; p = 0.016). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [4], [5] |
| KEGG Pathway | Renin-angiotensin system | |||
| Chagas disease (American trypanosomiasis) | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6374). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers. J Vet Intern Med. 2009 Sep-Oct;23(5):977-83. | |||
| REF 5 | Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. | |||
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