Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V0NJ
|
|||
| Former ID |
DNC012507
|
|||
| Drug Name |
2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine
|
|||
| Synonyms |
2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine; 5946-39-4; 2,3,4,5-tetrahydro-1H-1,4-benzodiazepine; CHEMBL323692; 1H-1,4-Benzodiazepine, 2,3,4,5-tetrahydro-; 2,3,4,5-tetrahydro-(1h)-1,4-benzodiazepine; 2,3,4,5-tetrahydro-1h benzo[e][1,4]diazepine; AC1MCKFZ; PubChem14772; ACMC-1ANOK; tetrahydrobenzo[1,4]diazepine; SCHEMBL379799; BEN206; BEN025; AC1Q1I93; KS-00001OTC; CTK1G9067; DTXSID20378071; MolPort-000-006-540; MLXBHOCKBUILHN-UHFFFAOYSA-N; ZINC2511438; STL554215; CT-889; BDBM50052888; MFCD03789577; BBL100421; AKOS005254212
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C9H12N2
|
|||
| Canonical SMILES |
C1CNC2=CC=CC=C2CN1
|
|||
| InChI |
1S/C9H12N2/c1-2-4-9-8(3-1)7-10-5-6-11-9/h1-4,10-11H,5-7H2
|
|||
| InChIKey |
MLXBHOCKBUILHN-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 5946-39-4
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
| Adrenergic receptor alpha-2B (ADRA2B) | Target Info | Inhibitor | [1] | |
| Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Integration of energy metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.