Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V2PB
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| Former ID |
DIB018397
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| Drug Name |
[3H]Ro 63-0563
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| Synonyms |
4-Amino-N-[2,6-bis(methylamino)pyridin-4-yl]benzenesulfonamide; Ro-63-0563; Ro 63-0563; CHEMBL46071; 4-amino-N-[2,6-bis(methylamino)pyridin-4-yl]benzenesulfonamide; AC1NSM3I; GTPL275; SCHEMBL679027; GTPL3246; Ro630563; BDBM50090524; Ro-630563; L000518; 4-Amino-N-(2,6-diamino-pyridin-4-yl)-benzenesulfonamide; N-(2,6-bis(methylamino)pyridin-4-yl)-4-aminobenzenesulfonamide; 4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulfonamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H17N5O2S
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| Canonical SMILES |
CNC1=CC(=CC(=N1)NC)NS(=O)(=O)C2=CC=C(C=C2)N
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| InChI |
1S/C13H17N5O2S/c1-15-12-7-10(8-13(16-2)17-12)18-21(19,20)11-5-3-9(14)4-6-11/h3-8H,14H2,1-2H3,(H3,15,16,17,18)
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| InChIKey |
PTFNKZLSFWJYFJ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 6 receptor (HTR6) | Target Info | Antagonist | [3], [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | |||
| Reactome | Serotonin receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3246). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 275). | |||
| REF 3 | The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum. Mol Pharmacol. 1998 Sep;54(3):577-83. | |||
| REF 4 | Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. | |||
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